Table 1 Study characteristics
Study | Sample Size (n) | Age (years) | Men n (%) | Severity | Type of balanced saline | Serum creatinine | Sepsis patients n (%) | Invasive mechanical ventilation patients n (%) | Cumulative volume of fluids (at first 24 h) (ml) | Cumulative volume of fluids during follow-up period | Mortality: follow-up period in days |
|---|---|---|---|---|---|---|---|---|---|---|---|
Finfer 2022 | 5037 | BS: 61.7(16.4)a | BS: 1578(62.7) | APACHE II BS: 19.0 (14.0–26.0)b | Plasma-Lyte 148 | BS: 127.4(109.8)a | BS: 1048(42.8) | BS: 1861(75.9) | BS: 1609c | BS: 3900 (2000–6700)b | 90 |
NS: 62.1(16.5)a | NS: 1511(59.9) | NS: 19.0 (14.0–25.0)b | NS: 125.9(112.0)a (μmol/L) | NS: 1023(41.8) | NS: 1881(76.8) | NS: 1522c | NS: 3700(2000–6300)b | ||||
Zampieri2021 | 11,052 | BS: 60.9(17.0)a | BS: 2909(55.6) | APACHE II BS: 12 (8–17)b | Plasma-Lyte 148 | BS: 1.2 (0.9)a | BS: 966 (18.5) | BS: 2304(44.2) | BS: 2078c | BS: 4100(2900)a | 90 |
NS: 61.2(16.9)a | NS: 2956(55.9) | NS: 12 (8–17)b | NS: 1.2 (0.9)a (mg/dl) | NS: 1015(19.2) | NS: 2340(44.3) | NS: 2096c | NS: 4100(2900)a | ||||
Young 2015 | 2278 | BS: 60.1(16.8)a | BS: 739 (64) | APACHE II BS: 14.1(6.9)a | Plasma-Lyte 148 | BS: 0.98 (0.76)a | BS: 41 (4) | BS: 768(67) | BS: 1226(653–2505)b | BS: 2000(1000–3500)b | In hospital |
NS: 61.0(16.3)a | NS: 746 (67) | NS: 14.1(6.7)a | NS: 0.99 (0.68)a (mg/dl) | NS: 43 (4) | NS: 731 (66) | NS: 1431(784–2340)b | NS: 2000(1000–3300)b | ||||
Young2014 | 65 | BS: 38(19)a | BS: 16 (73) | ISS BS: 24(18)a | Plasma-Lyte A | BS: 1.0 (0.3)a | NR | NR | NR | BS: 10,300(2900)a | 30 |
NS: 39(14)a | NS: 19 (79) | NS: 2 22(14)a | NS: 1.0 (0.2)a (mg/dl) | NS: 4100(6500)a | |||||||
Semler 2017 | 974 | BS: 57 (42–68)b | BS: 268 (51.5) | NR | Lactated ringer’s solution and Plasma-Lyte A | BS: 0.83 (0.67–1.09b | BS: 130 (25.0) | BS: 174 (33.5) | BS: 1597c | BS: 1600(500–3600)b | 60 |
NS: 58 (46–71)b | NS: 246 (54.2) | NS: 0.86 (0.69–1.12)b (mg/dl) | NS: 130 (28.6) | NS: 155 (34.1) | NS: 1238c | NS: 1400(500–3400)b | |||||
Semler 2018 | 15,802 | BS: 58(44–69)b | BS: 4540(57.2) | NR | Lactated ringer’s solution and Plasma-Lyte A | BS: 0.89(0.74–1.10)b | BS: 1167(14.7) | BS: 2723 (34.3) | BS: 1642c | BS: 1000(0–3210)b | 60 |
NS: 58(44–69)b | NS: 4557(58.0) | NS: 0.89(0.74–1.10)b (mg/dl) | NS: 1169(14.9) | NS: 2731 (34.7) | NS: 1506c | NS: 1020(0–3500)b | |||||
Verma 2016 | 67 | BS: 62(45–70)b | BS: 21(63.6) | NR | Plasma-Lyte 148 | BS: 85 (58–134)b | BS: 4 (12.1) | BS: 19 (57.6) | BS: 1090(620–2500)b | BS: 2900(1600–5600)b | In hospital |
NS: 64(46–72)b | NS: 21(61.8) | NS: 90 (60–121)b (μmol/L) | NS: 3 (8.9) | NS: 19 (55.9) | NS: 1275(435–2243)b | NS: 3400(1200–5800)b | |||||
Ratanarat 2017 | 181 | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR |