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Table 4 Values depicting selectivity of pentoxifylline for the different elimination pathways of cAMP and cGMP at temperatures ranging from 37 to 20 °C

From: Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Temperature

[PDE3-inhibition]/[PDE5-inhibition]

[cAMP-efflux inhibition]/[cGMP-efflux inhibition]

[PDE3-inhibition]/[cAMP-efflux inhibition]

[PDE5-inhibition]/[cGMP-efflux inhibition]

37 °C

2.05

2.50

11.9

14.5

34 °C

1.33

4.04

3.94

12.0

32 °C

1.72

2.78

13.3

21.4

28 °C

0.920

2.27

11.6

28.6

24 °C

1.16

–

–

50.2

20 °C

0.788

–

–

102

  1. Values are ratios between IC50-values
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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

ISSN: 1757-7241