Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study

Table 1 Q10-values for QT and QTc during mild (35–32 °C), moderate (32–28 °C) and severe (< 28 °C) hypothermia

Q10-values	hi-PSC-CM		Dietrichs et al	Thomsen et al		Yoon et al		Rosol et al		Salinas et al		Weitz et al		Kim et al
Parameter	APD90	APD90c	QTc	QT	QTc	QT	QTc	QT	QTc	QT	QTc	QT	QTc	QT	QTc
Mild hypothermia	3.2	2.3	1.4	1.4	1.1	2.4	1.4	2.0	1.3	1.6–2.2	1.3–1.5	2.1	1.6	2.1	1.3
Moderate hypothermia	2.9	2.3	1.2
Severe hypothermia	2.8	2.3	1.2

Data was derived from a literature search in PubMed for (therapeutic hypothermia) and (QT interval) and a search for (deep hypothermia) and (QT interval). Included papers had to report human, adult data from the last 10 years and report absolute QT or QTc. The search for deep hypothermia did not have to include data from the last 10 years. No case reports were included. Reference lists of included papers were screened for relevant papers. Thomsen et al. are estimated Q₁₀-value by deriving approximate numbers from graphs

ISSN: 1757-7241