Fig. 2
From: Frostbite treatment: a systematic review with meta-analyses

Meta-analyses of studies comparing thrombolysis and conservative treatment. Mean difference of the salvage rate of the Hennepin Frostbite Score (A) and risk ratio of the amputation probability of a digit at risk (B). The between-study variance τ2 was estimated by means of DerSimonian-Laird (A) and Paule-Mandel (B) methods. P-value refers to the heterogeneity test. I2, heterogeneity statistic; τ2, between-study variance; CI, confidence interval; MD, mean difference; N, numerosity; RR, risk ratio; SD, standard deviation; SR, salvage rate; tPA, tissue plasminogen activator