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Table 1 Patients characteristics and outcomes

From: The prevalence of clinically relevant delayed intracranial hemorrhage in head trauma patients treated with oral anticoagulants is very low: a retrospective cohort register study

  

All

n = 2,362

Warfarin use

n = 1,017

DOAC use

n = 1,310

PATIENT PARAMETERS

Value type

   

Age years

median (QR)

84 (77–89)

85 (79–90)

83 (76–89)

Women

n (%)

1,290 (54.6%)

535 (52.6%)

738 (56.3%)

Residency in Region Skåne

n (%)

2,333 (98.8%)

1,004 (98.7%)

1,294 (98.8%)

Ambulance arrival

n (%)

1,713 (72.5%)

737 (72.4%)

946 (72.2%)

INR

median (QR)

1.9 (1.2–2.6)

2.5 (2.1-3.0)

1.1 (1.0-1.3)

INR <2

n (%)

756 (32.0%)

115 (11.3%)

626 (47.8%)

INR ≥2 and ≤ 3

n (%)

541 (22.9%)

530 (52.1%)

11 (0.8%)

INR >3

n (%)

194 (8.2%)

192 (18.9%)

2 (0.2%)

Anticoagulation

    

Warfarin

n (%)

1,036 (43.9%)

1,017 (100%)

-

Dabigatran

n (%)

217 (9.2%)

-

211 (16.1%)

Rivaroxaban

n (%)

413 (17.5%)

-

394 (30.1%)

Apixaban

n (%)

725 (30.7%)

-

700 (53.4%)

Edoxaban

n (%)

7 (0.3%)

-

5 (0.4%)

30-DAY OUTCOMES

    

All-cause mortality

n (%, [CI])

112 (4.7%, [3.9–5.7%])

49 (4.8%, [3.6–6.3%])

62 (4.7%, [3.6-6.0%])

Neurosurgery

n (%, [CI])

6 (0.3%, [0.1–0.6%])

5 (0.5%, [0.2–1.1%])

1 (0.1%, [0.0-0.4%])

d-ICH all

n (%, [CI])

5 (0.2%, [0.1–0.5%])

2 (0.2%, [0.0-0.7%])

3 (0.2%, [0.0-0.7%])

d-ICH with Mortality

n (%, [CI])

2 (0.08%, [0.01–0.3%]

0 (0.0%, [0.0-0.4%])

2 (0.15%, [0.02–0.6%])

d-ICH with ICU admission

n (%, [CI])

0 (0.0% [0.0-0.2%])

0 (0.0%, [0.0-0.4%])

0 (0.0%, [0.0-0.03%])

d-ICH with Neurosurgery

n (%, [CI])

0 (0.0% [0.0-0.2%])

0 (0.0%, [0.0-0.4%])

0 (0.0%, [0.0-0.03%])

  1. CI : 95% confidence interval limits, Clopper-Pearson exact method
  2. QR : Quartiles range, exclusive, 25–75%
  3. INR : Prothrombin time, International Normalized Ratio
  4. DOAC: Direct Oral Anticoagulant
  5. ICU: Intensive Care Unit
  6. 35 cases had more than one redeemed oral anticoagulant prescription, likely representing a switch in therapy. These were omitted for separate statistics of Warfarin and DOAC groups. Neither of these patients had d-ICH findings.
  7. INR results were missing in 871 (36,9%) of the total cases; this includes 180 (17.7%) in the Warfarin group and 671 (51.2%) in the DOAC group