Table 2 Comparison of initial laboratory findings, amount of blood transfusion, and clinical outcomes based on the presence of hypofibrinogenemia in patients with primary postpartum hemorrhage
Variables | Hypofibrinogenemia group (n = 73) | No-hypofibrinogenemia group (n = 101) | p value |
|---|---|---|---|
Laboratory findings | |||
Lactate, mmol/L | 2.3 (1.8–3.2) | 2.2 (1.6–3.0) | 0.138 |
Hemoglobin, g/dL | 8.7 (7.8–10.1) | 10.9 (9.5–12.3) | < 0.001 |
Hematocrit, % | 27.6 (23.6–31.2) | 32.3 (29.8–36.7) | < 0.001 |
Platelet, × 103/uL | 125 (103–146) | 175 (148–214) | < 0.001 |
PT (INR) | 1.3 (1.2–1.6) | 1.1 (1.0–1.1) | < 0.001 |
FDP, ug/mL | 120 (57–125) | 34 (17–82) | < 0.001 |
D-dimer, ug/mL | 35.2 (11.8–35.5) | 10.9 (5.8–25.4) | < 0.001 |
Amount of blood transfusion (units) | |||
Packed red blood cells | 6.0 (4.0–11.0) | 3.0 (1.0–5.0) | < 0.001 |
Fresh frozen plasma | 5.0 (3.0–10.0) | 1.0 (0.0–4.0) | < 0.001 |
Platelet concentrate | 0.0 (0.0–8.0) | 0.0 (0.0–0.0) | < 0.001 |
Cryoprecipitate | 0.0 (0.0–3.0) | 0.0 (0.0–0.0) | 0.008 |
Clinical outcome | |||
Massive transfusion | 27 (37.0) | 5 (5.0) | < 0.001 |
Embolization | 50 (68.5) | 37 (36.6) | < 0.001 |
Hysterectomy | 1 (1.4) | 1 (1.0) | 1.000 |
Length of hospital stay, days | 2.0 (2.0–4.0) | 2.0 (1.0–3.0) | 0.003 |
ICU admission | 2 (2.7) | 5 (5.0) | 0.700 |
In-hospital death | 1 (1.4) | 0 (0.0) | 0.420 |