Table 2 Test performance for prediction of transfusion within 24-hours

Primary Outcome:

ANY abnormal VHA

Component*

AUROC 0.633

[0.531–0.736]

Sensitivity

73.6%

(59.7-84.7%)

Specificity

49.2%

(36.1-62.3%)

PPV

55.7%

(48.4-62.2%)

NPV

68.2%

(56.1-78.2%)

Abnormal

39 (34.2%)

31 (27.2%)

70 (61.4%)

Normal

14 (12.2%)

30 (26.3%)

44 (38.6%)

TEG6s

Activated Clotting Time (ACT)

Sensitivity

18.9%

(9.4-32.0%)

Specificity

80.3%

(68.2-89.4%)

PPV

45.5%

(28.2-63.9%)

NPV

53.3%

(48.8-57.7%)

Abnormal

10 (8.7%)

12 (10.5%)

22 (19.3%)

Normal

43 (37.7%)

49 (43.0%)

92 (80.7%)

R (min) CK

(Standard TEG)

Sensitivity

32.1%

(19.9-46.3%)

Specificity

77.1%

(64.5-86.9%)

PPV

54.8%

(39.9-69.0%)

NPV

56.6%

(50.9-62.2%)

Abnormal

17 (14.9%)

14 (12.2%)

31 (27.2%)

Normal

36 (31.5%)

47 (41.2%)

83 (72.8%)

K (min) CK

(Standard TEG)

Sensitivity

26.4%

(15.3-40.3%)

Specificity

88.5%

(77.8-95.3%)

PPV

66.7%

(46.6-82.1%)

NPV

58.1%

(53.5-62.5%)

Abnormal

14 (12.3%)

7 (6.1%)

21 (18.4%)

Normal

39 (34.2%)

54 (47.4%)

93 (81.6%)

a-angle (deg) CK

(Standard TEG)

Sensitivity

18.9% (9.44-32.0%)

Specificity

83.6%

(71.9-91.9%)

PPV

50.0%

(31.1-68.9%)

NPV

54.3%

(50.0-58.5%)

Abnormal

10 (8.8%)

10 (8.8%)

20 (17.5%)

Normal

43 (37.7%)

51 (44.7%)

94 (82.4%)

MA (mm) CK

(Standard TEG)

Sensitivity

28.3%

(16.8-42.4%)

Specificity

85.3%

(73.8-93.0%)

PPV

62.5%

(44.3-77.7%)

NPV

57.8%

(52.9-62.5%)

Abnormal

15 (13.1%)

9 (7.9%)

24 (21.0%)

Normal

38 (33.33%)

52 (45.6%)

90 (78.9%)

LY30 (%) CK

(Standard TEG)

Sensitivity

3.8%

(0.5-13.0%)

Specificity

96.7%

(88.7-99.6%)

PPV

50.0%

(12.7-87.3%)

NPV

53.6%

(51.9-55.4%)

Abnormal

2 (1.8%)

2 (1.8%)

4 (3.5%)

Normal

51 (44.7%)

59 (51.8%)

110 (96.5%)

ANY abnormal “Rapid” TEG

AUROC 0.582

[0.477–0.688]

Sensitivity

43.4%

(29.8-57.7%)

Specificity

73.8%

(60.9-84.2%)

PPV

59.0%

(46.0-70.8%)

NPV

60.0%

(53.2-68.7%)

Abnormal

23 (20.2%)

16 (14.0%)

39 (34.2%)

Normal

30 (40%)

45 (60%)

75 (65.8%)