Long-term outcomes of out-of-center veno-arterial ECMO cannulation for cardiopulmonary failure: investigation of prognostic parameters for a decision support tool – a 16-year retrospective study

Table 8 Disease dynamic and organ failure prior to Out-of-CenterVA ECMO CPC outcome

	Overall N = 345	CPC 1	CPC ≥ 2	p-value
Resuscitation prior to ECMO	227 (65.8%)	92 (60.9%)	135 (69.6%)	0.11
Ventilation days prior to ECMO	0 (0, 1)	0 (0, 1)	0 (0, 1)	> 0.9
Time from onset of illness to ECMO in days	0 (0, 1)	1 (0, 1)	0 (0, 1)	0.003*
Dialysis prior to ECMO	61 (17.7%)	16 (10.6%)	45 (23.2%)	0.002*
SOFA-score prior to ECMO	15 (13, 17)	14 (13, 17)	16 (14, 18)	< 0.001*
≥ 2 Organ failures prior to ECMO	182 (52.8%)	63 (41.7%)	119 (61.3%)	< 0.001*
Distance to implantation site in km	70 (45, 104)	72 (50, 110)	70 (43, 101)	0.11
	Overall N = 284	ECOG 0, 1	ECOG ≥ 2	p-value
Resuscitation prior to ECMO	186 (65.5%)	62 (58.5%)	124 (69.7%)	0.071
Ventilation days prior to ECMO	0 (0, 1)	0 (0, 1)	0 (0, 1)	0.8
Time from onset of illness to ECMO in days	1 (0, 2)	1 (0, 2)	1 (0, 2)	0.3
Dialysis prior to ECMO	50 (17.6%)	9 (8.5%)	41 (23.0%)	0.007*
SOFA-score prior to ECMO	15 (13, 18)	14 (12, 17)	16 (14, 18)	< 0.001*
≥ 2 Organ failures prior to ECMO	150 (52.8%)	44 (41.5%)	106 (59.6%)	0.005*
Distance to implantation site in km	70 (45, 102)	80 (60, 110)	70 (40, 95)	0.022

Presentation of disease severity due to perfusion disturbance with evidence of organ failures. Specifically, renal failure and the SOFA score, commonly used in sepsis to assess organ failures, are highlighted. Disease dynamics are scaled by the duration of ventilation prior to ECMO, as well as the time from the onset of illness to the need for ECMO therapy. Values were presented in number of patients (percentage) and main (QRS values) (25 th and 75 th percentiles). The significance level was set at p ≤ 0.05, and significant values are marked with an asterisk (*) in the table

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